IndraLab

Statements

USP18 activates JAK-STAT. 3 / 3
| 3
reach
"As far as IFN-alpha response is concerned, a prominent example is the modulation of JAK-STAT signalling by the ubiquitin peptidase USP18 [XREF_BIBR, XREF_BIBR]."
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reach
"Similarly, USP18, a ubiquitin-specific peptidase, is stimulated by JAK-STAT signaling and provides negative feedback to this pathway by binding IFNAR2, resulting in the promotion of viral replication [80]."
| PMC
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"Quantifying mRNA expression of negative regulators of JAK-STAT signaling such as SOCS1, SOCS3, and USP18, we observed significantly increased expression levels of USP18, which correlated with the ISG score (Fig. 4d)."
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