IndraLab

Statements

USP10 activates AR. 10 / 12
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"For example, USP10 stimulates AR transcriptional activity in the presence of its synthetic agonist R1881 [67]."
30217566
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"USP10 overexpression enhanced AR transcriptional activity whereas knock-down by specific siRNAs had the opposite effect."
16368182
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"USP10 appeared to modulate AR function."
18687060
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"Cell based transactivation assays in PC-3/AR cells revealed that overexpression of wild-type USP10, but not of an enzymatically inactive form, stimulated AR activity mediated by reporter constructs harbouring selective androgen response elements (AREs), non selective steroid response elements (SREs) or the mouse mammary tumour virus (MMTV) promoter."
16368182
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"The coactivating effects were observed with selective and non selective response elements, indicating that USP10 was a broad coactivator of the AR."
16368182
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"Usp10 is known to enhance AR transcriptional activity [XREF_BIBR, XREF_BIBR] and Usp22 and Usp26 have been found in complexes with AR [XREF_BIBR, XREF_BIBR]."
26462181
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"Overexpression of wild-type USP10 stimulated AR activity as revealed by reporter constructs harbouring selective androgen response elements, non selective steroid response elements or the mouse mammary tumour virus promoter."
28151478
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", confirming that USP10 is a bonafide co-activator of AR regulated transcription."
21245042
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"Usp10, another DUB reported to target AR, was also shown to enhance AR activity by combining both direct and indirect activity."
25216524
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"RNF6 and USP10, which modulate androgen receptor function, showed correlated genomic loss and lower expression in a subset of tumors and gain and higher expression in others."
19773449