IndraLab

Statements

USP25 activates Th1 Cells. 3 / 3
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"From our previous data, E3 deubiquitinase USP21 prevents the depletion of FOXP3 and restricts the generation of Th1-like Treg cells ."
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"Furthermore, another study showed that the depletion of USP21 induces the production of Th1 like Tregs as a result of unstable FOXP3 expression, leading to severe autoimmune systemic disorders [XREF_BIBR]."
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"Then, USP21 prevents Foxp3 degradation, which further enhances the transcription of Usp21 and suppresses Th1 like phenotypes."
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