IndraLab

Statements

COPS5 activates Cell Survival. 5 / 6
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"Jab1 mediated cell viability changes after UV and treatment with HU is tightly correlated with the lowered level of the 9-1-1 complex in cells)."
17583730
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"Knock-down of Csn5 and JAB1 clearly enhanced basal NF-kappaB activity and improved cell survival under stress."
19656241
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"Finally, we demonstrate that a novel, highly specific small molecule inhibitor of JAB1, CSN5i-3, reduces osteosarcoma cell viability, and has specific effects on the ubiquitin-proteasome system in OS."
32390003
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"The deletion of Jab1 in limb bud OPCs impairs cell survival and inhibits chondrogenesis, consequently leading to a severe limb shortening phenotype in Jab1 cKO mice."
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"These results suggest that overexpression of CSN5 may contribute to both cell survival and proliferation and thus represent a prognostic marker for malignant conversion in liver cancer."
21499307