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TP53 bound to BCL2L1 activates TP53. 3 / 3
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"This presumably dissociated the Bax/Bcl-xL interaction ( Ming et al., 2006 ) as well as p53/Bcl-xL interactions ( Chipuk et al., 2005 ) which together further allowed a direct and potent interaction o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"By binding to Bcl-xl, p53 induces Bax and Bak oligomerization in the outer membrane of mitochondria suppressing Bcl-2 and Bcl-xl expression and finally initiates p53-mediated mitochondria-dependent ap[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Importantly, loss of apoptotic ability of the 239–248 mutant correlated with loss of its BclXL binding ability, which suggests that p53/BclXL complex formation is necessary for p53 mediated OMM permea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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