IndraLab

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COPS6 activates Neoplasms. 14 / 15
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"In addition to orlistat, we evaluated another FASN inhibitor C75 for its effect on tumor growth advantage driven by CSN6."
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"With cell confluence assay and colony formation assay, we find that knockdown (KD) of CSN6 significantly inhibited tumor growth in HCC cell line in vitro (Figure S1D–F, Supporting Information)."
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"CSN6 mediates nucleotide metabolism to promote tumor development and chemoresistance in colorectal cancer."
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"CSN6 increased the tumor growth rate and tumor weight compared with vector control-transfected cells (Figure 6A-C)."
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"In this regard, Zou et al. reported that CSN6 mediates nucleotide metabolism to promote tumor development and chemoresistance in colorectal cancer (CRC) [85]."
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"More CSN6 positive signals and fewer p16 signals were observed in CSN6-overexpressing tumors than in the control group (Figure 6E)."
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"A colitis-associated colorectal cancer model established that Csn6 intestinal conditional deletion decreased tumor development and altered nucleotide metabolism."
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"It has been reported that CSN6 can promote some degree of tumor progression by regulating the stability of several E3 ligases6-8 ,21 ."
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"On the basis of our in vitro studies, we found that CSN6 overexpression significantly promoted the formation of tumors in nude mice."
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"COPS6 promotes tumor progression and reduces CD8 + T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer ."
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"COPS6 promotes tumor progression and reduces CD8+ T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer."
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"To demonstrate the impact of CSN6‐COP1 axis in regulating FOXO4 and subsequent gene expression of SGOC genes in vivo, we performed mouse xenograft cancer studies and demonstrated that CSN6 knockdown suppressed tumor growth (Figure S17C, Supporting Information)."
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"These data suggested that CSN6‐FOXO4 axis deregulation could exist in many types of cancer.In our cancer model study, CSN6 overexpression promoted cancer growth while CSN6 knockdown inhibited tumor growth in xenograft colon cancer model."
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"Both COPS6 and COPS9 knockdown also reduced viable HCC cell number after several days in culture as estimated by CCK8 assay, while overexpression significantly increased (Figure 11B), suggesting that COPS6 and COPS9 accelerate HCC tumor growth."
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