IndraLab

Statements

COPS6 activates Neoplasms. 7 / 8
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"To demonstrate the impact of CSN6‐COP1 axis in regulating FOXO4 and subsequent gene expression of SGOC genes in vivo, we performed mouse xenograft cancer studies and demonstrated that CSN6 knockdown suppressed tumor growth (Figure S17C, Supporting Information)."
33101846
eidos
"COPS6 promotes tumor progression and reduces CD8 + T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer ."
37095198
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"These data suggested that CSN6‐FOXO4 axis deregulation could exist in many types of cancer.In our cancer model study, CSN6 overexpression promoted cancer growth while CSN6 knockdown inhibited tumor growth in xenograft colon cancer model."
33101846
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"A colitis-associated colorectal cancer model established that Csn6 intestinal conditional deletion decreased tumor development and altered nucleotide metabolism."
36512632
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"COPS6 promotes tumor progression and reduces CD8+ T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer."
37095198
reach
"CSN6 mediates nucleotide metabolism to promote tumor development and chemoresistance in colorectal cancer."
36512632
eidos
"It has been reported that CSN6 can promote some degree of tumor progression by regulating the stability of several E3 ligases6-8 ,21 ."
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