IndraLab

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Hydroxychloroquine decreases the amount of IL6. 28 / 28
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"On the other hand, few studies have reported that HCQ could decease HIV-1 viremia, stabilize CD4 T cell count and reduce IL-6 and IgG levels in infected patients [ 159 ], although others showed contra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, we had to balance between possible risks and the efficacy of the investigational medication, and we wanted to be on the safe side.We conclude that hydroxychloroquine lowers IL-6 levels more t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Hydroxychloroquine, a drug that has been investigated in COVID-19, is also known to modulate the cytokine response and reduce IL-6 levels [ 89 ], though recent observational studies have not identifie[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast to lopinavir and ritonavir, chloroquine and hydroxychloroquine + azithromycin downregulated the expression of TNF and IL6."
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"In a retrospective observational study with 550 patients, in addition to the basic treatments for COVID-19, low doses of hydroxychloroquine significantly reduce the fatality and the serum level of pro-inflammatory IL-6 in severe COVID-19 patients [69]."
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"HCQ was reported to inhibit the release of IL-6, IL-1β and TNF-α (108–110)."
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"In a multicenter, double-blind, placebo-controlled trial, it was observed that HCQ treatment reduced the IL-6 levels in patients with non-rheumatic disease following MI."
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"Additionally, in a monocytic cell line, hydroxychloroquine attenuated TNF-alpha and IL6 expression in response to IL-1beta and TNF-alpha stimulation, respectively 46."
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"Hydroxychloroquine can also reduce salivary and serum levels of IL-6, a key component of the senescence associated secretory phenotype (SASP) in chronic inflammatory diseases, such as Sjogren 's syndrome."
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"Meanwhile, HCQ simultaneously inhibited autophagy of CAFs and melanoma cells, and down-regulated IL-6 and HMGB1 secretion, thus effectively inhibiting melanoma metastasis."
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"Similar remarks can apply to HCQ, which has been shown to improve skeletal muscle insulin sensitivity, enhance systemic glucose clearance, and concomitantly reduce circulating IL-6 levels in insulin-resistant adults [93]."
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"Other medications have also been applied to regulate the balance of inflammatory factors, such as hydroxychloroquine, which reduces the levels of IL-1, IL-2, IL-6, IL-17, IL-22, TNF-α, and IFN-γ [35] [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In another single-arm study, administration of hydroxychloroquine to HIV infected persons who experienced suboptimal CD4 T-cell gains after highly active antiretroviral therapy (HAART) resulted in decreased levels of T-cell activation and decreased levels of inflammatory cytokines IL-6 and TNF in plasma."
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"This notion, in fact, was partially endorsed by the new results from a multicenter, randomized, double-blind, placebo-controlled OXI pilot trial among 125 patients with MI in Finland, which indicated that early administration of HCQ within 48 h after MI (300 mg once daily for 6 months) significantly reduced serum levels of interleukin-6 (IL-6), a key pro-inflammatory marker and did not cause any significant adverse events [133]."
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"HCQ can inhibit the production of IL-1, IL-6, TNF-α, and IFN-γ in monocytes in vitro, as well as the secretion of TNF-α, IFN-α, IL-6, and other substances by plasmacytoid dendritic cells and natural killer cells (208, 210, 211)."
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"Hydroxychloroquine suppressed endosomal TLR-induced IFNalpha and IL-6 release in vitro."
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"This hypothesis, however, remains to be investigated, especially because the humoral response alone may not be sufficient to clear the infection.Considering the effect of drug treatment, hydroxychloroquine (HCQ), known for its anti-inflammatory properties, significantly reduced IL-6 levels, an effect already observed in patients affected by systemic lupus erythematosus (SLE), a chronic autoimmune disease [35, 36]."
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"Tang et al. [25] found that HCQ inhibited the expression levels of IL-1β, IL-6, and TNF-α to protect against ischemia/reperfusion (I/R)-induced renal injury, which is consistent with our observations."
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"In our study, it was observed that HCQ treatment drastically decreased the levels of IL-6 and TNF-α in sepsis-induced rats."
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"Finally, in a human first-trimester trophoblast cell line (SVneo-transformed HTR8 cells), HCQ was able to partially reverse the aPL-mediated inhibition of cell migration despite the observation that HCQ treatment increased the secretion of promigratory IL-6 by trophoblasts [57]."
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"Hydroxychloroquine inhibits IL-6, IL-1beta and TNF-alfa release ( Quiros Roldan et al., 2020 ), and it showed also anti-thrombotic properties interfering with platelet aggregation and blood clotting p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"10, 11 Treatment with HCQ also lowered IL-6 level in HIV patients, suggesting the agent may have immunosuppressive properties helpful in the prevention or treatment of cytokine storm associated with severe COVID-19 disease."
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"Here we observed, for the first time that hydroxychloroquine treatment decreased the IL-6 levels after myocardial infarction in patients who had no rheumatic disease."
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"In the present study, hydroxychloroquine lowered IL-6 levels but not those of CRP which implies that the anti-inflammatory effect of hydroxychloroquine may be limited just to IL-6."
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"Addition of HCQ suppressed the expression of IFN-α, IFN-β, TNF-α, and IL-6 in both G/G and A/A pDCs (Supplemental Figure 10, A and B)."
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"Yu and colleagues reported that HCQ treatment could reduce serum interleukin-6 (IL-6) levels in COVID-19 patients [8]."
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"In some trials, adding CQ/HCQ to cART reduced immune activation markers on CD8+ T cells or levels of activated CD4+/Ki67+ and CD14+/CD69+ T cells [113], whereas HCQ did not reduce CD8+ T-cell activation and IL-6/D-dimer levels in other trials, with an increase of viral replication and a decline in CD4+ T cell count [114,115]."
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"Among the 51 patients enrolled in the study, HCQ treatment led to significantly reduced serum levels of TNF-alpha, IL-6, IL-8, VEGF-A, IL-1ra, and IL-2 (p < 0.0001; p = 0.0006; p = 0.0460, p = 0.0177; p < 0.0001; p = 0.0282, respectively) and to decreased (but not significantly) levels of MIP-1alpha (p = 0.0746)."
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