IndraLab

Statements

TNFAIP3 inhibits MAP3K5. 7 / 7
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"However, TNFAIP3 (A20), which has both ubiquitin ligase and deubiquitinase activities, inactivates ASK1 in fatty-acid-induced cells and ameliorates NASH [ xref ]."
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"A20 signaling in APAP necrosis is through the MAPK cascade Since A20 is known to degrade ASK1 , thus abrogating JNK activation ( 26 ) , we examined JNK expression in A20HepCKO mice after APAP ."
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"Additionally , the same group has reported that TNFAIP3 can endogenously suppress ASK1 and reduce apoptosis , lipid accumulation , and inflammation [ 116 ] ."
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"The results from this study reveal a novel anti-apoptotic mechanism of A20 in TNF signaling pathway : A20 binds to apoptosis signal-regulating kinase1 ( ASK1 ) and mediates ASK1 degradation , leading to suppression of JNK activation and eventually blockage of apoptosis ."
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"Taken together , the results from this study reveal a novel anti-apoptotic mechanism of A20 in TNF signaling pathway : A20 binds to ASK1 and mediates ASK1 degradation , leading to suppression of JNK activation and eventually blockage of apoptosis ."
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"Additionally, the same group has reported that TNFAIP3 can endogenously suppress ASK1 and reduce apoptosis, lipid accumulation, and inflammation [XREF_BIBR]."
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"A20 reduces the stability and promotes the degradation of ASK1 through the ubiquitination process A20 restricts TNF-induced NF-kappaB signaling through its ubiquitin editing activity on RIP1 ,14,15 it is thus of interest to test whether A20 would be affecting the stability of ASK1 through a similar mechanism ."
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