IndraLab

Statements

USP46 inhibits RNF43. 2 / 2

| 2

reach

"In contrast, overexpression of the USP46 complex blocks ubiquitylation of LRP6 by the ubiquitin ligases RNF43 and ZNFR3."

37798301

➶

reach

"Because the USP46 complex opposes the action of RNF43 and ZNRF3, loss of USP46 would be expected to potentiate the activities of RNF43 and ZNRF3, decreasing the effectiveness of RSPO in maintaining intestinal organoid growth."

37798301

INDRA sources:

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IndraLab

Statements

USP46 inhibits RNF43. 2 / 2

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