IndraLab

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OTUD7B leads to the deubiquitination of GβL. 2 / 2
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"For example, OTUD7B activates mTORC2 by deubiquitinating and removing polyubiquitin chains from GβL, promoting its interaction with SIN1, which enhances AKT signaling and thereby contributes to lung tumorigenesis [12]."
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"7Bi treatment in NSCLC and HEK293 cells efficiently reduced Akt-pS473 signals by interfering with OTUD7B-directed GβL deubiquitination, leading to reduced cell growth."
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