IndraLab

Statements


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"Dofetilide, bepridil, and cisapride are high or intermediate-proarrhythmic-risk drug that prolongs the QT by blocking hERG."

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"Cisapride dramatically enhanced the rate of HERG current decay while having no apparent effect on the initial phase of current activation."

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"The main effect of cisapride was to enhance the rate of HERG current decay thereby reducing current at the end of the voltage clamp pulse."