IndraLab

Statements

Cisapride activates KCNH2. 6 / 6
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"Cisapride dramatically enhanced the rate of HERG current decay while having no apparent effect on the initial phase of current activation."
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"Tegaserod and cisapride only require a 10-fold higher concentration to activate 5-HT2A and hERG channels, respectively [24].4."
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"On the other hand, the application of 1 μM cisapride completely abolished the tail current of hERG ( Fig. 4 (B), n = 3), indicating that cisapride blocked the potassium current of hERG."
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"For example, cisapride (antiemetic) and astemizole (antihistamine) both produce cardiac arrhythmias by inhibiting an off-target, a cardiac ion channel hERG (human Ether-à-go-go -Related Gene) [17] ."
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"Dofetilide, bepridil, and cisapride are high or intermediate-proarrhythmic-risk drug that prolongs the QT by blocking hERG."
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"Cisapride stimulates hERG (human Ether-à-go-go -Related Gene, that codes for K v 11.1, a potassium channel), in contrast to tegaserod and other 5-HT 4 agonists.5-HT 3 antagonists such as ondansetron, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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