IndraLab

Statements


USP14 activates FASN. 4 / 4
| 4

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"USP14 directly interacts with and increases FASN stability."

reach
"In addition to USP2a, which is well known as a DUB that regulates the level of FASN, a recent study showed that Usp14 significantly contributes to the development of hepatosteatosis by maintaining the stability of FASN in MPHs [7,20]."
| PMC

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"Based on a previous finding that Usp14 is a novel DUB for FASN and enhances FASN stability by blocking proteasomal degradation in MPHs, we expected that a USP14 inhibitor IU1 could further reduce the activity of FASN by interfering with FASN stability when used together with a FASN inhibitor."
| PMC

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"Recently, Liu et al. reported that Usp14 increases FASN stability in mouse primary hepatocytes (MPHs)."
| PMC