IndraLab

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USP14 activates FASN. 8 / 8
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"In addition to USP2a, which is well known as a DUB that regulates the level of FASN, a recent study showed that Usp14 significantly contributes to the development of hepatosteatosis by maintaining the stability of FASN in MPHs [7,20]."
| PMC
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"USP14 directly interacts with and increases FASN stability."
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"Based on a previous finding that Usp14 is a novel DUB for FASN and enhances FASN stability by blocking proteasomal degradation in MPHs, we expected that a USP14 inhibitor IU1 could further reduce the activity of FASN by interfering with FASN stability when used together with a FASN inhibitor."
| PMC
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"USP14 can promote hepatic triglyceride accumulation by increasing the stability of fatty acid synthase (FASN), which is the crucial enzyme for hepatic adipogenesis (150)."
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"However, the mRNA expression of FASN was independent of USP14 overexpression (Fig. 4e), suggesting that USP14 modulates FASN at the posttranscriptional level."
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"For example, USP14 overexpression stimulates liver triglyceride accumulation by stabilizing fatty acid synthase [38]."
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"It is currently known that USP14 promotes hepatic triglyceride accumulation and produces steatosis by stabilizing FASN [ 15 ]."
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"Recently, Liu et al. reported that Usp14 increases FASN stability in mouse primary hepatocytes (MPHs)."
| PMC