IndraLab

Statements

USP14 activates FASN. 4 / 4
| 4
reach
"USP14 directly interacts with and increases FASN stability."
30425250
reach
"In addition to USP2a, which is well known as a DUB that regulates the level of FASN, a recent study showed that Usp14 significantly contributes to the development of hepatosteatosis by maintaining the stability of FASN in MPHs [7,20]."
| PMC
reach
"Based on a previous finding that Usp14 is a novel DUB for FASN and enhances FASN stability by blocking proteasomal degradation in MPHs, we expected that a USP14 inhibitor IU1 could further reduce the activity of FASN by interfering with FASN stability when used together with a FASN inhibitor."
| PMC
reach
"Recently, Liu et al. reported that Usp14 increases FASN stability in mouse primary hepatocytes (MPHs)."
| PMC