IndraLab

Statements

USP22 binds HIF1A. 8 / 8
2 | 6
biogrid
No evidence text available
31776228
biogrid
No evidence text available
31776228
sparser
"Moreover, USP22 and HIF1α formed a positive feedback loop and facilitating the development of HCC xref ."
40607251
sparser
"Our laboratory found that HIF-1α can bind to the USP22 promoter."
33989708
sparser
"While deubiquitinating enzymes are known to maintain target protein stability by antagonizing E3 ubiquitin ligase activity xref , our study provides novel evidence for USP22-mediated HIF-1α stabilization in CHF, confirmed through direct validation of USP22-HIF-1α binding and modulated ubiquitination."
41254007
sparser
"In TP53-mutant HCC cells, USP22 and HIF1α formed a positive feedback loop and promote the stemness of HCC."
31776228
sparser
"Mechanistically, USP22 bound to and stabilized HIF-1α protein by deubiquitination."
41254007
sparser
"Co-IP experiments confirmed that USP22 interacts with HIF-1α (Fig.  xref D)."
41254007