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USP22 activates E2F6. 3 / 3
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"Therefore, we validated the interaction of E2F6 and USP22; the results revealed that E2F6, a pocket protein-independent transcription repressor, was capable of interacting with USP22 ( Fig. 1 C–E), in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Notably, the reduction in the E2F6 protein level caused by USP22 inhibition could be reversed by the proteasome inhibitor MG132 ( Fig. 1 H), indicating that USP22 increased E2F6 stability by inhibitin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We then generated four signatures based on the transcriptional alterations caused by E2F6 or USP22 deletion, namely E2F6 ACTIVITY UP or USP22 ACTIVITY UP (the downregulated genes upon E2F6 or USP22 de[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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