IndraLab

Statements

Caffeine inhibits CASP1. 4 / 4
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"XREF_FIG demonstrate that caffeine but not NAC inhibits adenosine dependent activation of caspase 1 when adenosine is perfused into mice (XREF_FIG, main effect of treatment (P < 0.001)."
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"Unexpectedly, caffeine (XREF_FIG) and more importantly antagonism of the A1+ A2A ARs (XREF_FIG) prevented reoxygenation dependent activation of caspase 1 while NAC did not (XREF_FIG)."
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"The PCR results also indicated that caffeine significantly reduced caspase 1 activation rather than Caspase 1 mRNA and protein expression (Figure 3A, B and E)."
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"In our study, caffeine treatment of THP-1 macrophages followed by LPS/ATP stimulation downregulated NLRP3, Caspase 1 and IL-1β."
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