IndraLab

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"Therefore, BAP1 might be serve as a potential target for high-risk NB with amplified MYCN.However, Sime et al. found that BAP1 overexpression could also induce apoptosis to retard BE2C cells proliferation by releasing Bax through 14–3–3 protein interaction and reducing the Bcl-2 expression regardless of BAP1 DUB activity [28]."
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"In conclusion, BAP1 is a KLF5 DUB and BAP1 promotes basal breast cell proliferation, migration, tumour growth and metastasis partially through stabilizing KLF5 (XREF_SUPPLEMENTARY)."
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"For example, BAP1 expression can promote pro-oncogenic pathways, including breast cancer cell proliferation and radioresistance in head and neck cancer (19, 20)."
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"BAP1 depletion has also been shown to reduce cell proliferation through S-phase accumulation in MPM (14), while it is suggested to function primarily as a metastasis suppressor in uveal melanoma (21)."
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"Downregulation of BAP1 promotes proliferation, cell cycle progression, and invasion of ICC in vitro."
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"Similarly, Qin et al. showed that knockdown of BAP1 in several breast cancer cell lines inhibited cell proliferation, tumorigenicity and metastasis."
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"Taken together, these data revealed that downregulation of BAP1 promotes proliferation, G1 to S cell cycle progression, and invasion of ICC in vitro."
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"BAP1 loss reduced HAP1 cell adhesion/spreading (Fig. 1D) and proliferation (Fig. 1E), considered here to be readouts of cell fitness."
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"Our data also showed that BAP1 depletion inhibited colon cancer cell proliferation and tumor growth."
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"The ability of BAP1 to promote colon cancer cell proliferation, however, seems to be independent of this mechanism, since BAP1 depletion did not affect the levels of β-catenin and Axin."
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"Our data instead showed that BAP1 depletion suppressed replication fork progression with concomitant induction of replication stress and apoptosis, suggesting that BAP1 promotes colon cancer cell proliferation by increasing the rate of DNA replication."
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"Given that KLF5 plays an oncogenic role in colon cancer , BAP1 may also contribute to colon cancer cell proliferation and tumor growth via KLF5 stabilization.TG2-179-1 was identified based on its ability to inhibit the DUB activity of BAP1 as determined using the artificial substrate Ub-AMC."
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"In summary, despite the findings implicating BAP1 in suppression of proliferation XREF_BIBR, XREF_BIBR, some groups have reported that BAP1 promotes cell proliferation XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"Selective growth of double BAP1 and PRKAR2A-mutant hepatocytes in an environment stimulating liver ductal cell proliferation."
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"Consistently, Asada et al. reported that BAP1 depletion through CRISPR/Cas9 system substantially inhibited proliferation of several human AML cell lines with ASXL1 mutations [ 36 ]."
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"Furthermore, our previous studies demonstrated that BAP1, a novel upstream positive regulator of KLF5 in breast cancer, contributes to ESCC cells proliferation and migration through enhancing KLF5 expression and its downstream genes, including Cyclin D1 and FGF-BP1 [16]."
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"Our experiments revealed that BAP1 knockdown inhibited the proliferation of MEL290 cells and rendered them insensitive to Doxorubicin (Supplementary Fig. 5A, B)."
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"BAP1 promotes proliferation in HNSCC cells regardless of HPV status."
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"BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5."
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"Studies of the effects of BAP1 on cell proliferation have shown conflicting results, with some reporting that BAP1 suppresses cell proliferation, and others reporting that BAP1 enhances proliferation."
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"In both cell lines, knockdown of BAP1 significantly inhibited cell proliferation (P < 0.05; XREF_FIG and XREF_FIG) and clonogenic survival (XREF_FIG - XREF_FIG)."
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"BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells."
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"Reintroduction of BAP1 into BAP1 deficient mesothelioma cells either had no effect or modestly increased cell proliferation."
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"The ability of BAP1 reconstitution to restore cell proliferation in BAP1-deficient cells required its deubiquitylase activity."
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"These studies demonstrate that BAP1 deficiency slows the proliferation of UM cells through regulation of S6 phosphorylation."
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"Furthermore, we observed that BaP1 decreased angiogenesis, characterized by a significant decrease in the vascularization formed around the tumors, as well as reduced tumor proliferation evidenced by the reduced levels of Ki67 expression in the tumors treated with the compound.Overall, our data highlights BaP1 as a molecule with a potent and selective anticancer activity against CRC cells and as a very interesting agent to disturb and counteract the important roles of lysosome in cancer."
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"Moreover, BAP1 was found to stabilize the transcription factor KLF5 and subsequently promoted the breast cancer cell proliferation and tumor growth in vitro and in vivo [23]."
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"BAP1 promotes cell proliferation through KLF5."
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"However, BAP1 was shown to promote breast cancer cell proliferation and migration, and lung cancer growth and metastasis [11] ."
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"These results indicate that BAP1 promotes KLF5 positive breast cell proliferation in vitro."
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"These results confirmed that BAP1 promotes cell proliferation in vitro through KLF5 in part."
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"MTT, cell scratch and transwell migration assays showed that low expression of BAP1 significantly promoted the proliferation and migration of UVM cells."
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"BAP1 probably accelerates ECA109 cell migration and proliferation by increasing KLF5 expression [20]."
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"For instance, BAP1 overexpression could induce apoptosis to retard BE2C cells proliferation by releasing Bax through 14–3–3 protein interaction and reducing the Bcl-2 expression regardless of BAP1 DUB activity [28]."
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"42 Kruppel like factor 5 (KLF5) is stabilized by the DUB BRCA1 associated Protein 1 (BAP1), promoting breast cancer cell proliferation."
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"BAP1 promotes breast cancer cell proliferation and migration in vitro and tumour growth and lung metastasis in vivo."
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"In cutaneous melanoma cell lines, however, stable over-expression of BAP1 promoted cell growth while knockdown of BAP1 suppressed cell proliferation with concomitant decrease of survivin, an anti-apoptotic protein [17]."
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"Here, we show that BAP1 is upregulated in colon cancer cells and tissues and that BAP1 depletion reduces colon cancer cell proliferation and tumor growth."
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"In agreement with previous work in other cell types [XREF_BIBR, XREF_BIBR, XREF_BIBR], transient BAP1 loss decreased cell proliferation."
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"BAP1 interacts with Krüppel-like factor 5 (KLF5) to stabilize KLF5 and promotes proliferation of breast cancer cells42."
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"BAP1 contributes to colon cancer cell proliferation by accelerating DNA replication and suppressing replication stress and concomitant apoptosis."
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"Knockdown of BAP1 increases CCA cell proliferation, whereas overexpression of wild-type BAP1 significantly inhibits cell proliferation, suggesting that BAP1 exhibits tumor suppressive effects (9)."
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"Moreover, BAP1 is a DUB for the transcription factor KLF5 and depletion of BAP1 inhibits breast cancer cell proliferation and tumor growth in vitro and in vivo in an KLF5-dependent manner [23]."
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"In both cell lines , knockdown of BAP1 significantly inhibited cell proliferation ( P < 0.05 ; Fig. 1A and B ) and clonogenic survival ( Fig. 1C-F ) ."
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"XREF_BIBR showed that BAP1 overexpression in BAP1-null malignant pleural mesothelioma cell lines promoted cell proliferation and that BAP1 knockdown decreased proliferation in three malignant pleural mesothelioma cell lines."
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"Our data suggest that BAP1 promotes cell proliferation and migration , and enhances the expression of KLF5 and its downstream genes , including CyclinD1 and FGF-BP1 , in the esophageal carcinoma cell line ECA109 ."
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"We showed that BAP1 is upregulated in colon cancer cells and tissues and that BAP1 depletion reduces colon cancer cell proliferation and tumor growth."
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"BAP1 depletion by RNAi inhibit cell proliferation in three MPM cell lines [27] ."
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"Therefore, it is unlikely that BAP1 contributes to the survival and proliferation of colon cancer cells via the Apc/β-catenin pathway.BAP1 functions in both normal DNA replication and replication stress recovery."
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