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USP13 activates AKT. 6 / 7
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"Further experimental results confirmed that the USP13‐PRPF6 axis promoted the proliferation of HCC cells by modulating the AKT‐mTOR signalling pathway.In conclusion, we have demonstrated that USP13 can decrease the K48/63‐linked polyubiquitination of PRPF6, thereby stabilising this protein and promoting HCC cell proliferation via regulation of the AKT‐mTOR pathway (Figure 8C)."
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"Overall, USP13 facilitates the malignant progression of HCC cells through the upregulation of WWP1.Thus, we concluded that USP13 stabilized WWP1, and then activated the Akt/mTOR pathway."
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"Moreover, USP13 stabilized WWP1 by removing the K29- and K48-linked polyubiquitination chains from WWP1 and then activated the Akt/mTOR pathway in HCC."
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"By acting as an oncogene, USP13 affects HCC malignant progression through the WWP1-mediated Akt/mTOR pathway."
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"Wu et al demonstrate that amplification of USP13 in some NSCLC leads to enhanced AKT and MAPK signaling that sustains cancer progression ."
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"Importantly, USP13 modulated the AKT‐mTOR signalling pathway in a manner analogous to PRPF6 (Figures 6D,E)."
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