IndraLab

Statements

USP19 activates Neoplasms. 11 / 11
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"USP19 Positively Regulates Tumor Growth and Metastasis."
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"In vivo experiments showed that USP19 silencing reduces tumorigenicity and delays tumor onset and growth, and the opposite was observed upon wild type USP19 overexpression (but not when overexpressing a catalytically dead mutant, or a cytoplasmic version of USP19)."
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"Moreover, the downregulation of USP19 promoted tumor growth in a xenograft model."
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"USP19 Negatively Regulates p53 and Promotes Cervical Cancer Progression ."
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"Also, worth investigating is whether USP19 inhibitors are promising drugs against tumors in general, or only some specific types of tumors, like liver cancers with p53 deletions/mutations that originate in a NAFLD background.In conclusion, this study shows that p53 deletion/mutation increases USP19, which in turn stabilizes SOAT1, increases cholesterol esterification and accelerates tumor progression (Figure 1)."
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"USP19 depletion significantly diminished the tumor weight and tumor volume compared with shControl group ( Fig. 6 A–D)."
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"Furthermore, the authors of this study also showed that USP19 depletion decreased tumor growth and metastasis in vivo."
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"Therefore, anti-tumor or pro-tumor effects mediated by USP19-CY may differ depending on cancer subtype."
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"Additionally, USP19 depletion results in significant enrichment of apoptosis and reduces the growth of tumors in the mouse xenograft."
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"The results showed that USP19 knockdown suppressed the proliferation, anchorage-independent growth and xenograft tumor formation of DLBCL cells and arrested the cell cycle at the G1 stage."
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"They validated their results using in vivo models and observed that USP19 downregulation promoted tumor growth in a xenograft model."
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