IndraLab

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USP42 deubiquitinates ZNRF3. 3 / 3
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"ZNRF3 deubiquitination by USP42 stabilizes its surface retention and functions to downregulate Fzds (Hao et al. 2012; Koo et al. 2012; Colozza and Koo 2021; Giebel et al. 2021)."
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"USP42 deubiquitinates RNF43 (ring finger protein 43) and ZNRF3 (zinc and ring finger 3), and USP42 knockout blocks Wnt activity[57]."
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"Once RNF43/ZNRF3 is internalized and no longer appears on the cell surface, it leaves FZDs available, resulting in enhanced Wnt signaling.Gieble et al. unmasked another piece in the puzzle of RNF43/ZNRF3 regulation [29] when they elegantly demonstrated that USP42 deubiquitinates RNF43/ZNRF3, thus negating the actions of the R-spondin–LGR5 axis."
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