IndraLab

Statements

Temsirolimus inhibits ATXN3. 3 / 3
| 3
reach
"This analysis identified only 16 genes (XREF_TABLE) whose expression was decreased in transgenic ataxin-3 mice and increased in transgenic mice treated with temsirolimus."
20007218
reach
"Of the first three genes we looked at, we confirmed a decrease in expression of Usp15 and Grik2 between wild-type and ataxin-3 transgenic mice, which were reversed in mice treated with temsirolimus (XREF_FIG B)."
20007218
reach
"A drug that increases autophagy, temsirolimus, decreased ataxin-3 both in soluble and aggregate forms and reduced pathology in a SCA3-transgenic line."
21810454