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P5091 deubiquitinates MDM2. 1 / 1

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"As expected, both genetic ablation of USP7 gene (siRNA or somatic knockout) and pharmacological inhibition of USP7 protein (P5091) prevents USP7 from deubiquitinating HDM2, resulting in stabilization and accumulation of p53, as well as p21-induced growth arrest and cell death (Chauhan et al., 2012)."

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P5091 deubiquitinates MDM2. 1 / 1

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