IndraLab

Statements

BAP1 inhibits E3_Ub_ligase. 7 / 7
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"XREF_BIBR suggested that BAP1 inhibits the E3 ligase activity of BRCA1 in a manner independent of its deubiquitination activity."
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"In this regard, however, Nishikawa et al . xref suggested that BAP1 inhibits the E3 ligase activity of BRCA1 in a manner independent of its deubiquitination activity."
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"BAP1, a ubiquitin carboxy-terminal hydrolase, interacts with the RING finger domain of BARD1 to inhibit the E3 ligase activity of BRCA1/BARD1, protecting BRCA1 from proteasome-mediated degradation (37, 38)."
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"However, another study demonstrated that the E3 activity of BRCA1–BARD1 could be inhibited by BAP1, which mediates HR repair and confer radioresistance17."
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"The E3 ligase activity of the BRCA1-BARD1 tumor-suppressor complex is suppressed by the interaction of BAP1 with BARD1 through its deubiquitylation."
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"BAP1 acts as a tumor suppressor and inhibits E3 ligase activity in BRCA1/BARD1."
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"The BRCA1 associated protein 1 (BAP1), a de-ubiquitinating enzyme (DUB), also inhibits the E3 ligase activity of BRCA1-BARD1 (Nishikawa et al., 2009)."
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