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Calcium(2+) inhibits CASP1. 6 / 7
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"The lotr1 mutants display altered localization of CASP1, an essential protein for Casparian strip formation [9], disrupted Casparian strips, ectopic suberization of endodermal cells, and low accumulation of shoot calcium (Ca)."
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"The presence of a Ca chelator, Bapta, prevented the increased dmDNA-induced ROS generation (RFU, dmDNA+Bapta = 980 ± 169 vs. dmDNA = 2380 ± 401; P < 0.05) (Figure 6B) and caspase-1 activation (AU, LPS+dmDNA+Bapta = 0.9 ± 0.2 vs. LPS+dmDNA = 2.6 ± 0.4; P < 0.05) in endothelial cells (Figure 6C)."
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"Both ACA, a channel blocker that acts on several transient receptor potential (TRP) channels including TRPM2, and 3MFA, a TRPM2 specifical inhibitor [53,54], significantly suppressed Ca 2+ influx in U[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, it was determined whether caspase-1 cleavage, which is also an indication of NLRP3 complex activation, is inhibited by TRPM2 or intracellular calcium."
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"MtDNA may interact with different activation models of the NLRP3 inflammasome, such as k + efflux and Ca + signa.In C57BL/6 mice, diabetes reduced endothelium-dependent vasodilation and increased vasc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, our experiments showed that the Ca 2+ chelator, BAPTA-AM, did not completely inhibit caspase-1 activation and mitochondrial ROS production."
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