IndraLab

Statements


1 | 7

reach
"A mechanism by which N91-eIF3f inhibits HIV mRNA 3 ' end processing was suggested by the observation that eIF3f interacts directly with CDK11, both in vitro and in vivo."

reach
"These data suggest that the proper interaction of eIF3f, CDK11 and 9G8 is required for efficient HIV-1 pre-mRNA processing and viral gene expression."

reach
"To test whether a previously undescribed interaction between eIF3f and 9G8 exists and to confirm the previously reported interaction between CDK11 and eIF3f in our cell line, TE671, we performed co-immunoprecipitation experiments."

reach
"Together these results show that CDK11 and 9G8 both interact with eIF3f."

reach
"We demonstrate that the eIF3 p47 can interact with CDK11 in vitro and in vivo, and the interaction can be strengthened by stimulation of apoptosis."

reach
"We show that eIF3f specifically interacts with 9G8 and CDK11 and together they alter the 3 ' end processing of the HIV-1 pre-mRNA in a sequence specific manner."

reach
"We confirmed that eIF3f interacts with CDK11 and showed that there is a specific interaction between eIF3f and 9G8 in vivo."

No evidence text available