IndraLab

"In previous reports, LAMB3 is overexpressed in PTC upon microarray analysis. xref Moreover, LAMB3 can be aberrantly upregulated by promoter demethylation and induce gastric cancer. xref Furthermore, LAMB3 is related to lymphatic metastasis in lung cancer and affects the migration and invasion capacity in lung cancer cell lines. xref In esophageal squamous cell carcinoma, the expression of LAMB3 is significantly associated with the COL7A1 gene, which is useful for predicting the malignant properties of esophageal squamous cell carcinoma. xref Besides, in the model of human epidermal carcinogenesis, LAMB3 activates PI3K through interactions with collagen VI. xref Some researchers found that osteopontin and LAMB3 can bind to ITGB1, which are receptors for cellular adhesion to the ECM and affect adhesion in the microenvironment to enhance the migration and invasion of highly metastatic cells. xref These studies indicated that LAMB3 is an important gene associated with PTC that may affect the tumorigenesis and progression of different tumors."

"Osteopontin, LAMB3 and ITGB1 Expression Levels in Lung Cancer Are Associated with Advanced Clinical Stage, Histological Grade, and Lymph Node Metastasis."

"We found that the expression levels of osteopontin, LAMB3 and ITGB1 were significantly associated with lymph node metastasis, as these levels were significantly higher in lung cancer patients with lymphatic metastasis than in those without lymphatic metastasis."