IndraLab

Statements

OTUB2 deubiquitinates RIPK3. 3 / 3
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"OTUB2 overexpression reduced the total and K48-specific ubiquitination of RIPK3 (Fig. 5D,E)."
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"LN5P45 treatment reduced RIPK3 protein levels by increasing the K48 ubiquitination of RIPK3, further confirming that OTUB2 deubiquitinates RIPK3 through the enzymatic activity.Pharmacological inhibition of OTUB2 by LN5P45 significantly reduced ischemic stroke injury in mice, indicating that specific and potent OTUB2 inhibitors are competitive candidates for drugs treating ischemic stroke."
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"Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke."
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