IndraLab

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OTUD4 activates Neoplasms. 6 / 6
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"In vivo assays substantiate that OTUD4 deletion, when combined with regorafenib, drastically reduces tumor proliferation, showcasing potent synergistic antitumor activity."
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"We further revealed a role of TGF-β signaling in orchestrating the OTUD4/CD73 proteolytic axis that promotes tumor progression."
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"The results suggest that CDH1 and HIN1 methylation heterogeneity may increase tumor metastasis."
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"We also found that OTUD4 OE in tumor cells enhanced a tumor-promoting M2-like phenotype in TAMs, usually defined by the expression of CD163 (Figure 6G)."
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"The data support a tumor-promoting role of the OTUD4/CD73 proteolytic axis in vivo.Previous studies have indicated that elevated levels of CD73 are often associated with an increase in immunosuppressive cell populations such as Tregs, MDSCs, and tumor-associated macrophages (TAMs) (32, 33)."
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"Together, these results demonstrate that OTUD4 is a bona fide deubiquitinase targeting Snail1 for deubiquitination and stabilization.Since OTUD4 deubiquitinates and stabilizes Snail1, we next investig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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