IndraLab

Statements


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"These results indicated that the USP47-TCEA3 axis modulates cell pyroptosis and apoptosis and may serve as a target for therapeutic intervention in CRC."

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"USP47 binds to TCEA3 and regulates its deubiquitination and intracellular levels, thereby enhancing doxorubicin resistance in CRC cells. [ xref ] STAT3β treatment enhanced cisplatin sensitivity and GSDME‐dependent pyroptosis in ESCC cells; mechanistic tests showed that STAT3β treatment increased ROS levels in cisplatin‐treated cells, thereby activating caspase‐3 and GSDME and thus inducing pyroptosis."

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"USP47 binds to TCEA3 and regulates its deubiquitination and intracellular levels, thereby enhancing doxorubicin resistance in CRC cells."