IndraLab

Statements

USP10 deubiquitinates HDAC6. 6 / 6
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"XREF_FIG, wild-type USP10, but not the catalytically-inactive USP10CA mutant, significantly reduces HDAC6 ubiquitination in 293T cells (comparing lanes 3 and 4 in the top panel)."
32382008
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"Another previous study from Hu et al. also showed that the depletion of USP10 increased the K48-linked polyubiquitination of HDAC6 in the non-small-cell lung cancer (NSCLC) cell line H1299."
35627217
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"Next, we tested whether USP10 could deubiquitinate HDAC6."
32382008
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"USP10 deubiquitinates histone deacetylase 6 (HDAC6), which is highly expressed in NSCLC samples [194]."
35884607
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"Previous studies have reported that USP10 promotes cisplatin resistance by deubiquitinating HDAC6 in non-small cell lung cancer [44], and promotes tumor growth and proliferation by deubiquitinating TAZ/YAP in liver cancer [45]."
38321024
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"USP10 has been reported to confer cisplatin resistance in NSCLC by deubiquitinating and stabilizing HDAC6 [ 63 ]."
37838281