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Tamoxifen inhibits HCN4. 2 / 2

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"(Deep bradycardia, conduction defects, and high mortality of the tamoxifen induced HCN4 knockout in mice in XREF_FIG -study were not manifested in XREF_FIG -study which used much lower doses of tamoxifen)."

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"Tamoxifen-induced HCN4 knockout in the adult murine heart produces profound bradycardia and also atrioventricular (AV) block, indicating roles for HCN4 not just in the SAN but also in the AV node (Baruscotti et al., 2011)."

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Tamoxifen inhibits HCN4. 2 / 2

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