IndraLab

Statements

OTUD3 binds IREB2. 13 / 13
3 | 2 8
sparser
"Co-IP further confirmed the interaction between OTUD3 and IRP2 (Fig.  xref C)."
39415292
sparser
"These findings position the OTUD3-IRP2 axis as a promising therapeutic target for preventing iron-mediated neurodegeneration in PD, offering a novel approach to modify disease progression by maintaining proper iron homeostasis."
41204197
reach
"Co-IP further confirmed the interaction between OTUD3 and IRP2 (Fig. 2C)."
39415292
reach
"Subsequently, the interaction between OTUD3 and IRP2 was determined."
35490179
sparser
"OTUD3, a deubiquitinating enzyme of IRP2, interacts with IRP2 in the cytoplasm, and deubiquitinates and stabilizes the IRP2 protein in an iron-independent manner."
39415292
biogrid
No evidence text available
35490179
sparser
"The functional significance of the OTUD3-IRP2 axis is particularly evident in pathological states."
41437362
sparser
"Subsequently, the interaction between OTUD3 and IRP2 was determined."
35490179
sparser
"In line with this, hou et al. further broader significance of the OTUD3-IRP2 axis in PD iron homeostasis (Hou et al. xref )."
41204197
biogrid
No evidence text available
35490179
sparser
"Thus, this OTUD3-IRP2 axis represents an important mechanism governing brain iron homeostasis in PD pathophysiology."
41204197
biogrid
No evidence text available
35490179
sparser
"Therefore, the OTUD3-IRP2 axis serves as a pivotal molecular link connecting neuroendocrine disorders to downstream iron-induced toxicity in PD."
41204197