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BAP1 activates Mice. 4 / 4
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"These results further confirm that the eradication of MC38 cells triggered by Bap1 deletion is independent of PD-L1 expression.Moreover, the overexpression of human WT BAP1 in Bap1-KO MC38 cells promoted their growth in host mice (Supplementary Fig. 3g–j)."
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"The fact that we determined that highly penetrant, heterozygous pathogenic BAP1 null variants by themselves, as studied by Kadariya et al. , can initiate and drive MM tumorigenesis in mice absent asbestos exposure supports their conclusions, in agreement with Chanock ."
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"In this study, we identified a decreased expression pattern of BAP1 in septic mice, and its artificial upregulation of BAP1 enhanced survival of the model mice and ameliorated the pathological changes[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"BAP1 depletion inhibits the growth of colon tumors in xenograft mice."
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