IndraLab

Statements

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"We found that wedelolactone broadly inhibited NLRP3 inflammasome activation and pyroptosis and IL-1beta secretion."
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"We are confirmed that wedelolactone can restrict the activation of NLRP3 inflammasome and also inhibit the subsequent pyroptosis along with IL-1beta release."
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"Thus, wedelolactone prevented both LPS priming and NLRP3 inflammasome activation in multiple macrophages."
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"Collectively, these data conclude that wedelolactone at least partly potentiates the PKA signalling to limit NLRP3 inflammasome activation and pyroptosis."
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"3.1 Wedelolactone suppresses the NLRP3 Inflammasome activation."
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"In the present study, our results showed that wedelolactone suppressed NLRP3 inflammasome activation, pyroptosis and IL-1beta release in the macrophage."
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"30, 39 We next investigate whether wedelolactone could inhibit the NLRP3 inflammasome activation in MSU induced peritonitis and gouty arthritis in C57BL/6J mice."
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"Therefore, the therapeutic strategies of wedelolactone to decrease NLRP3 activity and target the pyroptosis could be useful for treating NLRP3 driven diseases, such as gout, cancer, type 2 diabetes, Alzheimer 's, Parkinson 's and cardiovascular diseases."
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"Our results conclude that wedelolactone can suppress NLRP3 inflammasome activation and pyroptosis through heightening PKA induced NLRP3 phosphorylation to exhibit therapeutic effects against NLRP3 related inflammatory diseases."
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