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USP15 decreases the amount of TP53. 2 / 2

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"USP15 can stabilize MDM2 and negatively regulate the protein level of p53, and inactivation of USP15 can induce tumor apoptosis and improve the antitumor T-cell response[14]."

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"Nevertheless, considering that USP15 maintains MDM2 protein level and negatively regulates p53 dependent gene transcription and apoptosis in cancer cells, USP15 may represent an excellent drug target for efficient cancer therapy [XREF_BIBR, XREF_BIBR]."

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USP15 decreases the amount of TP53. 2 / 2

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