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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TSPYL5 decreases the amount of USP7. 2 / 2

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"Recently, TSPYL5 as an inhibitory protein for HAUSP was identified repressing the expression of HAUSP gene XREF_BIBR."

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"To explore the mechanism underlying downregulation of the USP7 level by TSPY1 and TSPYL5, we treated cells overexpressing TSPY1 and TSPYL5 with a protein biosynthesis inhibitor, cycloheximide (CHX), and observed more obvious degradation of USP7; this effect could be inhibited by MG132 treatment."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...