IndraLab

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TSPYL5 decreases the amount of USP7. 3 / 3
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"To explore the mechanism underlying downregulation of the USP7 level by TSPY1 and TSPYL5, we treated cells overexpressing TSPY1 and TSPYL5 with a protein biosynthesis inhibitor, cycloheximide (CHX), and observed more obvious degradation of USP7; this effect could be inhibited by MG132 treatment."
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"Recently, TSPYL5 as an inhibitory protein for HAUSP was identified repressing the expression of HAUSP gene XREF_BIBR."
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"TSPYL5 is frequently overexpressed in breast cancer, and the study showed that an increasing level of TSPYL5 decreased USP7/HAUSP expression and led to the accumulation of p53 ubiquitination [29]."
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