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HCN4 inhibits ion channel. 1 / 1
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"To test these possibilities, the effect of blockade of Na v 1.5 and HCN4 on the spontaneous activity of right atrial preparations was investigated -- if the age dependent decrease in the intrinsic heart rate is the result of a decline in either I Na or I f, blockade of the corresponding ion channel should have a smaller effect on the heart rate in the older animal."