IndraLab

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AKT activates KCNH2. 7 / 7
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"HERG channel activity was further increased by coexpression of PKB, an effect augmented by additional coexpression of PIKfyve, but not by additional coexpression of PKB and Akt resistant PIKfyve mutant PIKfyve (S318A)."
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"Moreover, our data from caPKB experiments indicate that any further increase in PKB activation may further increase I HERG beyond the basal conditions."
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"To clarify whether AKT mediate the modulation of Kcnh2 during SICD, we treated Kcnh2 +/- rats with bpV (HOpic), an activator of AKT, which has been proved to markedly enhance the phosphorylation level of AKT."
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"Whether these sites are responsible for HERG modulation by PKB merits further studies with site directed mutagenesis."
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"There are three possible mechanisms for the pilsicainide induced increase of hERG proteins via post-translational modifications : (1) phosphorylation of Akt, (2) activation of hsp expressions, and (3) direct action as a chemical chaperone."
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"Our data clearly indicate that HERG K + channel function in HEK293 cells is enhanced by PKB activation and also provide the evidence for the first time that PKB phosphorylation participates in K + cha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The quantitative data are presented in Fig. 4C where the ratios of staining intensity in positively stained cells over non stained control cells are shown.We demonstrated here that prevention of PI3K [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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