IndraLab

Statements

3',5'-cyclic AMP phosphorylates KCNQ1. 2 / 2
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"The results of these experiments, summarized in XREF_FIG, indicate that KCNQ1 is phosphorylated in response to cAMP independent of co-expression of any of these beta subunits."
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"These results confirmed the key role of the AO state in modulating the cAMP-dependent phosphorylation of both KCNQ1 and I channels.To further validate the predominant role of the AO state for cAMP sensitivity, we then proceeded to investigate whether other compounds with the ability to modulate the AO state can likewise enhance the cAMP sensitivity."
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