IndraLab

Statements


APC_C inhibits USP37. 2 / 2
| 2

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"Other APC CDH1 substrates, including CDC20, CDC6, PLK1, Aurora kinase A, and SKP2, were not decreased by USP37 knockdown, indicating a specific effect of USP37 on cyclin A abundance.Coimmunoprecipitat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"USP37 antagonises APC/C to stabilise Cyclin A at S-phase entry (Huang et al, 2011), whilst OTUD7B (Cezanne) exhibits K11-linkage specificity (Mevissen et al, 2013) and deubiquitinates both Cyclin B1 and Aurora A (Bonacci et al, 2018)."