IndraLab

Statements

BRAF-V600E activates phosphorylated ERK. 5 / 5
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"Consistent with previous findings, p-ERK activation by the RAS-independent mutation BRAF V600E was not affected by D154Q."
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"Inductions of the expression of BRAF V600E, V600K, K601E, L597Q, G469A, G469V, or G464V at levels comparable to those of endogenous BRAF caused significant induction of p-MEK and p-ERK and marked inhibition of RAS-GTP and pCRAF S338."
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"Transient expression of BRAF V600E for 48h also increased p-ERK accompanied by increased global histone acetylation, while expression of WT-BRAF did not have such effects (XREF_FIG, middle panel), confirming the specific effect of BRAF V600E on histone acetylation."
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"However, AZ138, a V600E mutant BRAF specific inhibitor, paradoxically activated p-ERK in wild type BRAF cell lines (Fig. 1d)."
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"The BRAF V600E mutation, which approaches 50% in human melanomas, constitutively activates pERK and contributes to disease progression."
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