IndraLab

Statements

BRAF-V600E activates phosphorylated ERK. 4 / 4
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reach
"Induction of the expression of BRAF V600E, V600K, K601E, L597Q, G469A, G469V, or G464V to levels comparable to those of endogenous BRAF caused significant induction of p-MEK and p-ERK and marked inhib[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26343582
reach
"The BRAF V600E mutation, which approaches 50% in human melanomas, constitutively activates pERK and contributes to disease progression."
24460976
reach
"Inductions of the expression of BRAF V600E, V600K, K601E, L597Q, G469A, G469V, or G464V at levels comparable to those of endogenous BRAF caused significant induction of p-MEK and p-ERK and marked inhibition of RAS-GTP and pCRAF S338."
26343582
reach
"Transient expression of BRAF V600E for 48h also increased p-ERK accompanied by increased global histone acetylation, while expression of WT-BRAF did not have such effects (XREF_FIG, middle panel), confirming the specific effect of BRAF V600E on histone acetylation."
24243688