IndraLab

Statements

TRESK-MT2 inhibits KCNK2. 2 / 2
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"Expression of TRESK-MT2 in TG neurons of mice inhibited TREK-1 and TREK-2, reduced the rheobase, and increased the firing rate, indicating greater excitability."
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"fsATI leads to the production of a second protein fragment, TRESK-MT2, which co-assembles with and inhibits TREK1 and TREK2, two other two-pore-domain K+ channels, to increase trigeminal sensory neuron excitability, leading to a migraine-like phenotype in rodents."
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