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"In additional experiments , Lu and colleagues crossed mice with DC specific heterozygous deletion of A20 with lymphocyte-deficient recombination activating gene ( Rag-1 ) knock out mice and found that this abrogated the hypertensive response to low dose angiotensin II , suggesting that loss of A20 in DCs contributes to angiotensin II induced hypertension in a T cell-dependent manner ."