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Berberine inhibits JUN. 7 / 7
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"The results of this study demonstrated that RC extract and berberine inhibit the production of monocyte chemoattractant protein 1 (MCP-1 and CCL2) in macrophages, likely via inhibition of the transcription factors activator protein 1 (AP-1) and nuclear factor-kappaB (NFkappaB)."
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"In addition, studies showed that the inhibitory effects of berberine were mediated by downregulating cellular c-Jun N-terminal protein kinase (JNK) and NF-kappa B activation (Hayashi et al. 2007), suppressing mitogen-activated protein kinase (MAPK) or MAPK/ERK kinase 1 (MEK)/extracellular signal-regulated kinase (ERK) signalling (Shin et al. 2015; Varghese et al. 2016)."
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"The electrophoretic mobility shift assay revealed that activator protein 1 (AP-1) binding was decreased in oral cancer cells treated with berberine for 2 h. Further analysis showed that berberine inhibited AP-1 binding directly."
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"It has been reported that berberine decreases the motility and invasion of non small lung cancer cells by alleviating the activation of c-Fos, c-Jun, and NF-kappaB, and thus inhibits uPA, MMP2 proteins [XREF_BIBR]."
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"Previous studies have shown that berberine reduced prostaglandin E2 production in vitro (in the oral cancer cell line and KB cells) and in vivo (in carrageenan induced air pouch in rats), moreover berberine inhibited activator protein 1, a key transcriptional factor in inflammation and carcinogenesis [XREF_BIBR]."
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"Fukuda et al. [13] reported that berberine inhibits the activity of activator protein 1 (AP-1), which transactivates inflammatory cytokines such as IL-6 [14]."
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"Previous studies have shown that berberine reduced prostaglandin E2 production in vitro (in the oral cancer cell line and KB cells) and in vivo (in carrageenan induced air pouch in rats), moreover berberine inhibited activator protein 1, a key transcriptional factor in inflammation and carcinogenesis [ xref ]."
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