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USP2-69 activates KCNQ1. 2 / 2
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"We find by electrophysiology, biochemistry, and confocal microscopy that both USP2-45 and USP2-69 counter the Nedd4-2-dependent ubiquitylation and thereby restore the plasma membrane localization of K[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Expression of USP2-69 together with KCNQ1 and Nedd4-2 partially restored the membrane localization of KCNQ1."