IndraLab

Statements

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"POH1 Knockdown Induces Apoptosis of Cancer Cells via Mitochondrial Pathway."
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"p53 or Bim siRNA markedly decreased the apoptosis driven by POH1 depletion."
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"In addition, the intratumoral injection of POH1 siRNAs decreased tumor growth and induced apoptosis in vivo."
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"These data suggest that the intratumoral injection of POH1 siRNA decreased tumor growth and induced apoptosis in vivo."
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"These data suggest the critical role of p53 and Bim in POH1 mediated apoptosis."
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"In vitro knockdown of PSMD2, but not PSMD14, increased the apoptosis, gemcitabine's toxicity and inhibited the growth capacity of MIA cells."
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"We observed that p53 and Bim siRNA markedly decreased the apoptosis driven by POH1 depletion."
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"As p53 siRNA and Bim siRNA failed to completely inhibit the apoptosis driven by POH1 depletion, the effect of POH1 knockdown may, at least in part, be dependent on p53 and Bim."
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"POH1 depletion, on the other hand, induces cell apoptosis by increasing stability and inhibiting ubiquitination of p53 and Bim."
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"The intratumoral injection of POH1 siRNAs decreased tumor growth and induced apoptosis in vivo."
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"POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim 1 2 3 4 5."
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"Inversely, PSMD14 depletion weakened E2F1 expression and promoted the apoptosis of SCC15 and UM1 cells treated with CDDP (XREF_SUPPLEMENTARY A-B)."
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"Third, although previous studies have shown that PSMD14 could mediate cell apoptosis (Wang et al., 2018), we only evaluated the impact of PSMD14 on cell proliferation."
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"Knockdown of p53 or Bim Decreased Apoptosis Mediated by POH1 Depletion."
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"Increased cleaved PARP levels have also been identified in the PSMD14 knockdown model, which leads to apoptosis [90]."
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"Intratumoral injection of POH1 small interfering RNA (siRNA) significantly reduced the progression of tumor growth and induced apoptosis in vivo."
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"Furthermore, p53 or Bim siRNA markedly attenuated the apoptosis induced by POH1 depletion."
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"We assessed if p53 and Bim were involved in apoptosis mediated by POH1 depletion."
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"Recent studies have demonstrated that p53 is stabilized in PSMD14-knockdown cells and that depletion of PSMD14 may induce cancer cell apoptosis mediated by p53 activation XREF_BIBR."
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"To detect the apoptosis induced by POH1, we first transfected QGY-7701, EC109, and HCT116 cells with POH1 or scrambled siRNA for 48 hours."
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