IndraLab
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"Nevertheless, whether miR-652-3p regulates that the OTUD5/PTEN axis has not been discussed before and warrants further exploration.In light of the abovementioned evidence, we put forth a hypothesis that OTUD5 deubiquitinates and stabilizes PTEN to suppress NSCLC cell proliferation, invasion, and migration, whereas this mechanism could be counteracted by miR-652-3p overexpression."
reach
"The obtained findings revealed that OTUD5 deubiquitinated and stabilized PTEN to suppress NSCLC proliferation, invasion, and migration, and miR-652-3p serving as an upstream target of OTUD5 abolished the tumor-suppressing role of OTUD5/PTEN in NSCLC.There is a plethora of evidence to highlight the correlation between decreased levels of OTUD5 and poor prognoses in NSCLC patients, such that OTUD5 knockdown exerts an enhancing effect on NSCLC cell proliferation, migration, and chemoresistance [13]."