IndraLab

Statements

USP22 increases the amount of CD274. 3 / 3
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"Increased USP22 transcription under the influence of PRDM1 upregulates PD-L1 transcription, mediated through SPI1 deubiquitination and degradation, which subsequently causes CD8 + T cell exhaustion [5[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, it was demonstrated that targeting USP22 via the miR-30-5p family inhibited the induction of PD-L1 expression in hypoxic conditions, thus preventing activated Tcells from killing LUAD cells."
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"Herein, we found that USP22-induced deubiquitination of SPI1 dominantly enhanced PD-L1 transcription."
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