IndraLab

Statements

IL10 binds CD4. 49 / 49
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"Anti-CD3 mAb treatment triggered the formation of significantly fewer IL-10 + CD4 + T cells in both NOD."
36973489
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"LCs suppress contact hypersensitivity by interaction with cognate CD4 + T cells in the context of IL-10 [ xref ]."
33523413
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"Inflammatory cytokines (IL-1β, IL-6, IL-12, and TNF-α) were also produced in TLR-stimulated cultures, but only IL-10 was significantly associated with sustained increases in CD4 T-cell levels."
22693231
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"Combined transcriptome and MR analysis results indicate that TNF-CD4 + T cells and IL-10-CD4 + T cells may be the two inflammatory regulatory axes of RA."
39304950
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"This protection was associated with an increase of IL-10-producing CD4 + T cells in the colonic lamina propria of these mice."
26269949
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"Indeed, it has been shown that dendritic cell activation via the asialoglycoprotein receptor leads to the formation of interleukin 10-producing CD4-positive suppressor cells, which could, in fact, hav[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28593860
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"The transcription factor cMaf is essential for IL-10 transcription in macrophages and upregulation of cMaf is associated with IL-10 expression in CD4 + T cells [ xref , xref ]."
28158245
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"Other populations, such as CD4 + /CD25 + /FoxP3 + Tregs, have been associated with the secretion of high levels of IL-10, thereby suppressing Th1, Th2, and Th17 responses."
23484125
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"Notably, these elevated responses in the absence of IL-10 were not associated with altered levels of regulatory CD4 T (Treg) cells as no differences in the percentages or numbers of Treg cells was discernable between the WT and IL-10 −/− groups ( xref )."
27402701
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"We show that CD4 IL10 production is associated with high-parasite antigen burden, consistent with other infections as well as non-infectious disease models ( xref , xref )."
29097996
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"IL-10 + DCs are known to stimulate CD4 + IL-10-cell formation in vitro and in vivo – these cells are able to suppress T-cell proliferation and trigger FoxP3 + T-reg cells ( xref – xref )."
39161770
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"In our cohort, it was specifically monofunctional IL10 CD4 T cells that were associated with a reduced risk of symptomatic malaria following Pf infection; high frequencies of these cells were significantly associated with reduced odds of symptomatic malaria when infection."
29097996
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"Monofunctional IL10 CD4 T cells were associated with high antigen burden and/or repeated infections, and were associated with protection from symptoms once infected."
29097996
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"Moreover, the total frequencies of CD4-IL-10 + T cells correlated positively with spleen size and negatively with HB, platelet, and lymphocyte levels."
38410517
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"To identify the factors involved in NK/DC interactions that could promote CD4 T cell priming in the absence of IL-10, we established an in vitro co-culture system with purified populations of NK cells, DCs and virus-specific CD4 T cells."
22876184
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"FACS analysis revealed that IL-10 production was associated with CD4 + T cells that also produced IFNγ, and therefore may be associated with an IL-10-secreting type 1 cell phenotype."
26436865
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"CD4 CD8αα IELs are producers of Treg-associated cytokines IL-10 and TGF-β, and can suppress Th1-induced intestinal inflammation in an IL-10-dependent manner to protect the mucosal barrier (151)."
35493508
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"Next, we wanted to determine if CD4 T cells are associated with the transient increased IL-10 production observed 10 months into both SCIT and SLIT treatment."
26436865
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"To determine if the IL-10 production is associated with CD4 T lymphocytes, CD3 + CD4 + cell subpopulation were gated on and the relative production was assessed."
26436865
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"LCs have been shown to interact directly with CD4-positive T cells in lymph nodes, secreting IL-10 and thus inhibiting the initiation of T cell activity [ xref ]."
24277309
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"However, the effect of shCD73 on inducing the formation of the IL-10-positive CD4 + T cell subsets described above was weakened, and the formation of CD4 + IFN-γ + T cells in the presence of shCD73 wa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37657243
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"Immunologic reconstitution and induction of tolerance following HLA-mismatched transplantation of hematopoietic stem cells (HSC) were associated with the presence of IL-10-producing CD4 + T cells [ xref ]."
21592823
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"In CD4-deficient mice, this was associated with a decreased IL-10 concentration after Hem plus CLP ( xref )."
19641139
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"We previously reported that a subset of CD4 T-cells secreting high levels of the immunosuppressive cytokine interleukin-10 (IL-10) is significantly associated with late onset of type 1 diabetes and is constitutively present in a majority of nondiabetic individuals."
20299476
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"Increased HBsAg levels were significantly associated with lower expression of CD4 + T cells IL-10 + , as indicated by multivariate analysis ( P  = 0.033)."
30832595
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"IL-10 + CD4 + T cells expressed the highest levels of IKZF3 both ex vivo and after activation compared with IL-10–CD4 + T cells."
32321757
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"As Fig. 8 showed, hPMSCs can regulate the secretion of IFN-γ and IL-10 in CD4 + T cells through the CD73/AMPK pathway and promote the formation of CD4 + IL-10 + T cell subsets, thereby upregulating th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37657243
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"To confirm that CD4 + T cells and macrophages interact to induce high levels of IL-10 expression, macrophages were reconstituted with CD4 + T cells, CD4 + T and NK cells, or whole T cells (CD3 + cells)."
24330710
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"CD4 + HLA-G + CD25 - FoxP3 - Tregs (XREF_FIG, XREF_FIG, XREF_TABLE) suppress T cell proliferation through the expression of membrane bound HLA-G1 and secretion of IL-10 and sHLA-G5 in a reversible, cell-contact independent and cell-contact dependent manner."
32655556
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"Additionally, a lack of protection was associated with IL-10 production and impaired antigen presentation to CD4 + cells."
26344751
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"Does Arg1 causes MCMV persistence, or does the virus persistence in the SG trigger the formation of IL-10-producing Arg1 positive CD4 T cells?"
37440306
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"Previous study has reported the regulatory role of mast cells in that they interact with conventional CD4 + T cells to generate IL-10 producing regulatory T cells through the axis of ICOSL/ICOS xref ."
25197971
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"Most IL-10-secreting CD4 T cells are characteristically associated with mucosal immunity, food tolerance, and antimicrobial immunity."
20510731
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"Assessment of the cellular immunity brought to light a distinct subpopulation of IFN-γ- and IL-10-expressing memory SARS-CoV-2 S-specific CD4 + T-cells that are formed only in the previously infected group and in the naïve group."
39340081
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"We determined that colitis in the IL10 −/− CD4 + ➔RAG −/− mice was associated with a decrease in retinal function, as assessed by electroretinography (ERG). xref provides example ERG signals from a PBS➔RAG −/− mouse and an IL10 −/− CD4 + ➔RAG −/− mouse, with the signals from each mouse obtained at four flash intensity settings (0.1, 1, 4, and 16, as described in the Methods)."
23899539
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"Treg-cell levels were evaluated by flow cytometry (Treg cells identified as CD3 (+) CD4 (+) CD25 (high) CD127 (low)) and by mRNA expression of forkhead box P3 or of Treg associated cytokine interleukin 10."
20539016
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"To further confirm the role of the Nrf2 signaling pathway in the generation of CD4 + IL-10 + T cells, expression of Nrf2, its downstream region, and expression of NF-κB were also analyzed during the formation of CD4 + IL-10 + T cells from naive CD4 + T cells."
34187557
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"Previous studies have indicated that Nrf2 and NF-κB can competitively translocate into the nucleus [ xref ]; thus, the levels of Nrf2 and NF-κB in the nucleus of CD4 + IL-10 + T cells were further determined during the formation of CD4 + IL-10 + T cells from naive CD4 + T cells."
34187557
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"IL-10 interacts directly with CD4 + T cells and suppresses neutrophils, eosinophils, and mast cells in lungs; it also inhibits production of IL-4 and IL-5 by T H 2 cells. xref , xref As a result, IL-10 plays a crucial role in asthma and lung inflammation; xref it has been shown that microbiota metabolites, such as SCFAs, can promote IL-10 production to maintain intestinal homeostasis."
38585449
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"As shown in Fig. 6 , VitD3/Dex treated small intestinal CD11c + DCs significantly increase the secretion of IL-10 ( Fig. 6 A) and down-regulation of co-stimulatory molecules (CD86) ( Fig. 6 B) within [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26874324
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"THαβ immunity is triggered by type 1 interferon and interleukin-27 (IL-27), and the main effector cells of the THαβ immune response are IL10-CD4 T cells, CD8 T cells, NK cells, and IgG1-producing B cells."
36914565
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"However, IL-27 impairs control of acute mouse hepatitis replication and associated pathology following infection of the CNS and this phenotype is associated with reduced accumulation of IL-10 + CD4 + T cells [ xref ]."
27926930
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"After 96 h, VitD3/Dex treated DCs showed an increased frequency of CD4-IL-10 + T cells ( Fig. 6 C)."
26874324
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"Thus, these results suggest that acarbose may not directly influence the capacity of intestinal DCs to induce CD4-IL-10 + T cell development."
26874324
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"Treatment was associated with elevated IL-10 + CD4 + T cells in lung tissue."
19528258
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"Reduced proliferative responses to allergen were associated with increased IL-10 production from PBMC and induction of functional CD4 + regulatory T cells ( xref )."
19528258
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"The main T helper cells of THαβ immunity are IL-10-CD4 T cells, formerly called Tr1 cells [ xref ]."
36914565
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"The major effector cells of THαβ immunity are IL-10-CD4 T cells, NK cells, CD8 T cells, and IgG1-producing B cells."
36914565
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"CD4 + MLN T cells from B. animalis monoassociated IL-10-/- mice secreted high levels of IFN-gamma and IL-17 in response to B. animalis lysate."
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