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Statements

USP35 inhibits FUNDC1. 2 / 2
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"Moreover, USP35 knockdown accelerated FUNDC1 degradation, while excessive USP35 inhibited FUNDC1 degradation in these cells (Fig. 4G and H)."
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"Therefore, endogenous USP35 is not essential for the neuroprotective effects of hUC-MSCs and their EVs in this context.Notably, our study only revealed that overdosed exogenous USP35 encapsulated in hUC-MSC-EVs inhibits apoptosis and mitochondrial damage by stabilizing FUNDC1 in OGD/R-induced SH-SY5Y cells at the cellular level."
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