IndraLab

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USP22 activates ITGB1. 3 / 3
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"Therefore, USP22 appears to regulate the expression of multiple integrin family members with b1 as the dominant one.We then focused on studying the functional consequences of USP22-mediated integrin b1 upregulation and assessed whether USP22 maintains breast CSC self-renewal and promotes breast cancer metastasis through integrin b1 upregulation by ectopic reconstitution of ITGB1 in USP22 knockout cells (Figure s2C-E)."
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"Collectively, these results demonstrate that USP22 enhances BCSCs tumorigenic potential, in part, through integrin b1 upregulation."
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"We then focused on studying the functional consequences of USP22-mediated integrin β1 upregulation and assessed whether USP22 maintains BCSCs self-renewal and promotes breast cancer metastasis through integrin β1 upregulation by ectopic reconstitution of ITGB1 in USP22 knockout cells (Figures S2C–S2E)."
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